************************************************************************* The Whiting School of Engineering The Johns Hopkins University INAUGURAL PROFESSORIAL LECTURE ************************************************************************* Carey E. Priebe November 29, 2001 Department of Mathematical Sciences Arellano Theatre (note change) The Johns Hopkins University Seminar: 3:00 p.m.(note change) Reception: 4:00 pm ************************************************************************* INVESTIGATING THE STRUCTURE OF HIGH DIMENSIONAL PATTERN RECOGNITION PROBLEMS ************************************************************************* ABSTRACT Statistical pattern recognition (classification, clustering, etc.) in high dimensions is notoriously difficult -- the "curse of dimensionality" implies that 'enough' data will never be available. Nevertheless, high dimensional pattern recognition applications such as hyperspectral target recognition and gene expression monitoring require methodologies for uncovering structure, generating hypotheses, and making decisions. This talk will discuss some of the challenges presented by high dimensional pattern recognition problems, and will introduce a "statistical data mining" methodology for investigating the structure of these problems. Applications from artificial olfactory analysis (the Tufts University "artificial nose") and gene expression monitoring by DNA microarrays will be used to frame the discussion.